Svetlana Viktorovna Demyanenko
+7(918) 509-21-85
Chairman
Southern Federal University
Senior researcher
Academy of Biology and Biotechnologies
Research interests:
Neurobiology, signaling pathways, epigenetic regulation, neuroprotective therapy
14.10.2021 - D.Sc Biosciences, with a major Biochemistry and Рathological physiology) Pirogov Russian National Research Medical University (Moscow, Russia). Title:” Signal and epigenetic processes of brain damage and protection after ischemic stroke”. Advisor: Prof. Anatoly B. Uzdensky
09.2000-07.2003 - Ph.D. (Biosciences, with a major Biochemistry) Rostov State University (Russia). Title: “Effect of nootropic drug GVS-111 on free radical processes in the brain and blood of rats of different anxiety level”. Supervisor: Prof. Alexander M. Mendzheritsky
09.1991-06.1996 - Specialist degree (Biologist, with a major Biochemistry), Rostov State University (Russia). Thesis: “Effect of the delta-sleep inducing peptide and piracetam on the balance neurotransmitter amino acids by the action of hyperbaric oxygen”. Supervisor: Prof. Alexander M. Mendzheritsky
PUBLICATIONS:
Reviews
- Demyanenko S, Dzreyan V, Sharifulina S. Histone Deacetylases and Their Isoform-Specific Inhibitors in Ischemic Stroke. Biomedicines. 2021; 9(10):1445. (IF: 6,08)
- Demyanenko S, Sharifulina S. The Role of Post-Translational Acetylation and Deacetylation of Signaling Proteins and Transcription Factors after Cerebral Ischemia: Facts and Hypotheses. Int J Mol Sci. 2021;22(15):7947. (IF: 5,92)
- Uzdensky AB, Demyanenko S. Histone acetylation and deacetylation in ischemic stroke. Neural Regen Res. 2021;16(8):1529-1530. (IF: 5,14)
- Rodkin S.V., Dzreyan V.A., Demyanenko S.V., Uzdensky A.B. The Role of p53-Dependent Signaling Pathways in Survival and Death of Neurons and Glial Cells after Peripheral Nerve Injury. Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology. 2021; 15 (4): 334 - 347
- Uzdensky AB, Demyanenko SV, Bibov MY. Signal transduction in human cutaneous melanoma and target drugs. Curr Cancer Drug Targets. 2013;13(8):843-66. (IF: 3,43)
Experimental papers since 2019
- Demyanenko SV, Pitinova MA, Dzreyan VA, Kalyuzhnaya YN, Eid MA, Abramov AY, Evgen'ev MB, Garbuz DG. The Role of p53 Protein in the Realization of the Exogenous Heat Shock Protein 70 Anti-Apoptotic Effect during Axotomy. Cells. 2021;11(1):93. (IF: 6,60)
- Sharifulina S, Dzreyan V, Guzenko V, Demyanenko S. Histone Methyltransferases SUV39H1 and G9a and DNA Methyltransferase DNMT1 in Penumbra Neurons and Astrocytes after Photothrombotic Stroke. Int J Mol Sci. 2021;22(22):12483. (IF: 5,92)
- Demyanenko SV, Uzdensky A. LIM kinase inhibitor T56-LIMKi protects mouse brain from photothrombotic stroke. Brain Inj. 2021;35(4):490-500. (IF: 2,24)
- Demyanenko S, Nikul V, Rodkin S, Davletshin A, Evgen'ev MB, Garbuz DG. Exogenous recombinant Hsp70 mediates neuroprotection after photothrombotic stroke. Cell Stress Chaperones. 2021;26(1):103-114. (IF: 3,30)
- Demyanenko SV, Dzreyan VA, Neginskaya MA, Uzdensky AB. Expression of Histone Deacetylases HDAC1 and HDAC2 and Their Role in Apoptosis in the Penumbra Induced by Photothrombotic Stroke. Mol Neurobiol. 2020 Jan;57(1):226-238. (IF: 5,59)
- Demyanenko SV, Nikul VV, Uzdensky AB. The Neuroprotective Effect of the HDAC2/3 Inhibitor MI192 on the Penumbra After Photothrombotic Stroke in the Mouse Brain. Mol Neurobiol. 2020; 57(1):239-248. (IF: 5,59)
- Demyanenko SV, Dzreyan VA, Uzdensky AB. Overexpression of HDAC6, but not HDAC3 and HDAC4 in the penumbra after photothrombotic stroke in the rat cerebral cortex and the neuroprotective effects of α-phenyl tropolone, HPOB, and sodium valproate. Brain Res Bull. 2020;162:151-165. (IF: 4,08)
- Demyanenko SV, Dzreyan VA, Uzdensky AB. The Expression and Localization of Histone Acetyltransferases HAT1 and PCAF in Neurons and Astrocytes of the Photothrombotic Stroke-Induced Penumbra in the Rat Brain Cortex. Mol Neurobiol. 2020 Jul;57(7):3219-3227. (IF: 5,59)
- Demyanenko S, Gantsgorn E, Rodkin S, Sharifulina S. Localization and Expression of Sirtuins 1, 2, 6 and Plasticity-Related Proteins in the Recovery Period after a Photothrombotic Stroke in Mice. J Stroke Cerebrovasc Dis. 2020;29(10):105152. (IF: 2,14)
- Demyanenko S, Dzreyan V, Uzdensky A. Axotomy-Induced Changes of the Protein Profile in the Crayfish Ventral Cord Ganglia. J Mol Neurosci. 2019;68(4):667-678. (IF: 3,10)
- Demyanenko S, Berezhnaya E, Neginskaya M, Rodkin S, Dzreyan V, Pitinova M. Сlass II histone deacetylases in the post-stroke recovery period-expression, cellular, and subcellular localization-promising targets for neuroprotection. J Cell Biochem. 2019;120(12):19590-19609. (IF: 4,24)
- Demyanenko S, Uzdensky A. Epigenetic Alterations Induced by Photothrombotic Stroke in the Rat Cerebral Cortex: Deacetylation of Histone h3, Upregulation of Histone Deacetylases and Histone Acetyltransferases. Int J Mol Sci. 2019;20(12):2882. (IF: 5,92)
Research projects:
2021-2023: Russian Science Foundation N 21-15-00188: “The role of post-translational acetylation and deacetylation of signaling proteins and transcription factors in ischemic penumbra after photothrombotic stroke” - Head of the Project
2021: Russian Ministry of Science and High Education N 075-15-2021-994: “Neuroprotective activity of exogenous Hsp70 and drugs for the treatment of neurodegeneration” - Head of the Project
2020-2022: Russian Ministry of Science and High Education N 0852-2020-0028: “Biochemical and molecular-genetic studies of the mechanisms of pathological processes associated with socially significant diseases” - Head of the Project
2018-2020: Russian Science Foundation N18-15-00110: “Investigation of epigenetic and signal processes, regulating neurodegeneration and neuroprotection in the penumbra after photothrombotic stroke in the rat cerebral cortex” - Principal Researcher
2016-2018: Russian Foundation for Basic Research N16-04-01135-a: ''The role of histone deacetylases in the postischemic recovery of the brain'' - Head of the Project
2014-2017: Russian Science Foundation N14-15-00068: "Investigation of intracellular signaling processes controlling neurodegeneration and neuroprotection in the penumbra after a local photothrombotic infarction in the cerebral cortex" - Principal Researcher
2014-2017: Russian Foundation for Basic Research N14-04-00741-а: "Signal and epigenetic mechanisms of ischemic tolerance developing in the nervous tissue under photoinduced ischemia” - Principal Researcher
2013-2015: Norwegian Cancer Society and the Southeastern Norway Regional Health Authority N 5705376: "The role of UVA radiation in melanoma initiation, progression and metastasis" - Visit Researcher
2011-2014: Russian Foundation for Basic Research N. 11-04-01476-a: "Proteomic analysis of the regulation of gene expression and chromatin rearrangements in the nervous tissue under photo-oxidative damage" - Principal Researcher
2013: Ministry of Education and Science of the Russian Federation N 213.01-24 / 2013-38 (N 01201178795): "Complex neurochemical, proteomic and ultrastructural study of cell-molecular mechanisms of neurodegeneration and neuroprotection in photo-induced stroke" - Researcher
2010-2012: Ministry of Education and Science of the Russian Federation N16.740.11.0368: "Epigenetic mechanisms of human melanoma formation" - Researcher
2011: Ministry of Education and Science of the Russian Federation N 01201178795: "Investigation of the regenerative activity of the carotenoid fraction of Deinococcus radiodurans in the model of a full-thickness cutaneous skin on the background of type I diabetes in mice" - Researcher
2010: Project "Practical use of Skulachev ions." LLC "Mitotechnology": "Study of the effect of SkQ1 on the estradiol level in the serum of female reproductive-age rats" - Researcher
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