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Senior researcher
Research Institute of Physical and Organic Chemistry
Degree: Doctor of Sciences
Research interests:
Chief Researcher, Head of the Laboratory of Sub- and Supercritical Fluid Technologies (Research Institute of Physical and Organic Chemistry of of the Southern Federal University).
Area of scientific interests: secondary plant metabolites, sub- and supercritical fluid technologies, HPLC-MS, antioxidant activity, antibacterial activity, supramolecular complexes.
Development of environmentally friendly extraction methods for a wide range of secondary metabolites from plant raw materials of the Russian Federation using subcritical water.
Development of a methodology for using mass spectrometry with electrospray ionization to determine the composition of plant extracts and study the processes of formation of self-associates of plant metabolites and non-covalent complexes with drugs widely used in medical practice.
Synthesis and study of a series of supramolecular complexes of pentacyclic triterpene glycosides and their aglycones (glycyrrhetinic acid and hederogenin) with widely used drugs (levomycetin, simvastatin, streptomycin, benzimidazole, etc.) both in traditional organic solvents and in subcritical water. Using the methods of mass spectrometry, HPLC, NMR, IR, absorption spectroscopy, data on the physicochemical characteristics of the synthesized supramolecular complexes were obtained, on the basis of which the qualitative and quantitative composition of the complexes was studied.
Study of the antioxidant activity of plant alkaloids glaucine (GL) and des-glaucine (d-GL) using a bioluminescent biosensor based on the E. coli strain MG1655 (pKatG-lux) and in the DPPH test.
Research projects:
Projects:
1. Ministry of Science and Higher Education of the Russian Federation (state assignment in the field of scientific activity, project no. 0852-2020-0031).
2.The Russian Foundation for Basic Research (grant no. 19-33-90211-Aspiranty).
3. An internal grant from Southern Federal University (Project No. VnGr-07/2017-04).
Scientific results obtained with the support of grants:
RFBR N 11-03-12141-ofi-m, AVCP N 2.2.2.2/3915, SFU Grant N213.01-24/2013-48, Projects (government task): N1895, N3.8.11, N3.6.12(3.5193.11 ) GR 01.2012.53106, grants of the President of the Russian Federation: NSh-3233.2010, NSh-927.2012.3, FTP - GK N16.740.11.0600, RFBR: N13-0-01318 A, N 13-03-12271-ofi-m.
Obtained 6 patents (Russian Federation):
1) Patent for invention N2395484 “Method of obtaining cyclotriveratrilene”, authors Bicherov A.V., Vetrova E.V., Borisenko N.I., Borisenko S.N. December 18, 2008
2) Patent for invention N2395488 “Method of obtaining pharmaceutically acceptable salts of des-glaucine”, authors Bicherov A.V., Borisenko N.I., Borisenko S.N., Vetrova E.V. 18.12.2008
3) Patent for invention N2395516 “Method for obtaining ivy saponins”, authors Borisenko S.N., Tikhomirova K.S., Borisenko N.I., Vetrova E.V. 12/18/2008
4) Patent for invention N2395515 “Method for obtaining Aralia aralosides”, authors Borisenko S.N., Maksimenko E.V., Borisenko N.I., Vetrova E.V. 27.07.2010
5) Patent for invention N2385734 “Method of obtaining glycyrrhetinic acid”, authors Mandzhieva S.S., Borisenko S.N., Tikhomirova K.S., Borisenko N.I., Vetrova E.V. 24.12.2008
6) Patent for invention N 2333207 priority dated June 06, 2006 “Method for obtaining quercetin”, authors Borisenko N.I, Borisenko R.N.
List of publications for 2015-2022:
1) Khizrieva S.S., Borisenko S.N., Maksimenko E.V., Zharkova G.V., Borisenko N.I. Khimiya Rastitel'nogo Syr'ya, 2022, No. 2, pp. 137–146. (in Russ.). DOI: 10.14258/jcprm.20220210519.
2) Khizrieva S.S., Borisenko S.N., Maksimenko E.V., Borisenko N.I., Minkin V.I. Study of the Composition and Anti-Acetylcholinesterase Activity of Olive Leaf (Olea europea L.) Extracts Obtained in Subcritical Water // Russian Journal of Physical Chemistry B, 2021, Vol. 15, No. 8, pp. 1286-1290.DOI: 10.1134/S1990793121080108. RSCI, Web of Science Core Collection, Scopus, Impact factor 0.823 (2020). (https://link.springer.com/article/10.1134/S1990793121080108).
3) Maksimenko E.V., Khizrieva S.S., Borisenko S.N., Lekar A.V., Borisenko N.I., Minkin V.I. Subcritical Water Extraction as a Means of Isolating Oleanolic Acid from an Olive Leaf (Olea europaea L.) // Russian Journal of Physical Chemistry B, 2021, Vol. 15, No.7, pp. 1196-1199. DOI: 10.1134/S1990793121070083. RSCI, Web of Science Core Collection, Scopus, Impact factor 0.823 (2020). (https://link.springer.com/article/10.1134/S1990793121070083).
4) Khizrieva S.S., Borisenko S.N., Maksimenko E.V., Borisenko N.I. Evaluation of different extraction techniques for the assay of anti-acetylcholinesterase activity of olive leaves (Olea europaea) // Chimica Techno Acta, 2021, Vol. 8, No. 4, pp. 20218403. DOI: 10.15826/chimtech.2021.8.4.03. Scopus, Impact factor 0.1 (Scopus, 2020). (https://journals.urfu.ru/index.php/chimtech/article/view/5124).
5) Khizrieva S.S.,Vetrova E.V., Borisenko S.N., Maksimenko E.V., Borisenko N.I. Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with Plants Flavonoids // Chimica Techno Acta, 2021, Vol. 8, No. 2, pp. 20218202. DOI: 10.15826/chimtech.2021.8.2.02. Scopus, Impact factor 0.1 (Scopus, 2020). (https://journals.urfu.ru/index.php/chimtech/article/view/4978).
6) Khizrieva S.S., Borisenko S.N., Maksimenko E.V., Vetrova E.V., Borisenko N.I., Minkin V.I. Antioxidant properties and effects of aporphine alkaloids and their phenanthrene seco-isomers on acetylcholinesterase activity// Khimija Rastitelnogo Syrja ("Chemistry of plant raw material"). 2021. No. 2. P. 237-246. (in Russ.). (http://journal.asu.ru/cw/article/view/8752).
7) Khizrieva S.S. , Vetrova E.V., Borisenko S.N., Maksimenko E.V., Borisenko N.I. Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with pentacyclic triterpenes of licorice // Chimica Techno Acta, 2020, Vol. 7, No. 4, pp. 192-198. DOI: 10.15826/chimtech.2020.7.4.10. Scopus, Impact factor 0.1 (Scopus, 2020). (https://journals.urfu.ru/index.php/chimtech/article/view/4808).
8) Lekar A.V., Maksimenko E.V., Borisenko S.N., Khizrieva S.S., Borisenko N.I., Minkin V.I. “One-Pot" Technique for Transformation of the Aporphine Alkaloid Boldine into Phenanthrene Seco-Boldine with Subcritical Water // Russian Journal of Physical Chemistry B, 2020, Vol. 14, No. 7, pp. 1153-1157. DOI: 10.1134/S199079312007012X. RSCI, Web of Science Core Collection, Scopus, Impact factor 0.823 (2020). (https://link.springer.com/article/10.1134/S199079312007012X).
9) Borisenko S.N., Lekar A.V., Maksimenko E.V., Khizrieva S.S., Borisenko N.I., Minkin V.I. Synthesis of Phenanthrene Alkaloids in Subcritical Water Using Secoboldine as an Example // Chemistry of Natural Compounds, 2020, Vol. 56, No. 1, pp. 183-184. DOI: 10.1007/s10600-020-02981-9. RSCI, Web of Science Core Collection, Scopus, Impact factor 0.809 (2020). (https://link.springer.com/article/10.1007/s10600-020-02981-9).
10) Lekar A.V., Maksimenko E.V., Borisenko S.N., Khizrieva S.S., Vetrova E. V., Borisenko N.I., Minkin V.I. One-Pot Technique for Production of Oleanolic Acid from the Roots of Aralia Mandshurica with Subcritical Water // Russian Journal of Physical Chemistry B, 2019, Vol. 13, No. 8, pp. 1273-1278. DOI: 10.1134/s1990793119080049. RSCI, Web of Science Core Collection, Scopus, Impact factor 0.823 (2020). (https://link.springer.com/article/10.1134/S1990793119080049).
11) Lekar A.V., Maksimenko E.V., Borisenko S.N., Khizrieva S.S., Vetrova E.V., Borisenko N.I., Minkin V.I. One-Pot Synthesis of Glycyrrhetinic Acid from Licorice Root in Subcritical Water // Russian Journal of Physical Chemistry B, 2019, Vol. 13, No. 7, pp. 1150-1154. DOI: 10.1134/s1990793119070170. RSCI, Web of Science Core Collection, Scopus, Impact factor 0.823 (2020). (https://link.springer.com/article/10.1134/S1990793119070170).
12) Vetrova Ye.V., Borisenko N.I., Lekar A.V., Maksimenko Ye.V., Borisenko S.N., Khizriyeva S.S. Mass spectrometry of glycyrrethenic acid complexes with striptomycines // Khimiya Rastitel'nogo Syr'ya. 2019. No. 1. P. 119-126. (in Russ.). (http://journal.asu.ru/cw/article/view/3319).
13) Maksimenko E. V., Lekar A.V., Borisenko, S. N., Khizrieva S.S., Vetrova E.V., Borisenko N. I., Minkin V.I. The Development of a One-Step Method for Production of the Antioxidant Quercetin from Flower Buds of the Sophora Japonica (Sophora japonica L.) in a Subcritical Water Medium // Russian Journal of Physical Chemistry B, 2018, Vol. 12, No. 8, pp. 1269-1275. DOI: 10.1134/s1990793118080092. RSCI, Web of Science Core Collection, Scopus, Impact factor 0.823 (2020). (https://link.springer.com/article/10.1134/S1990793118080092).
14) Maksimenko E.V., Lekar A.V., Khizrieva S.S., Borisenko S.N., Vetrova E.V., Borisenko N.I., Minkin V.I. Novel eco-friendly “One-Pot" facile strategy for production of the natural quercetin from the plant: A model study // Journal of Natural Science, Biology and Medicine, 2018, Vol. 9, No. 2, pp. 278-281. DOI: 10.4103/jnsbm.jnsbm_161_17. Scopus, Impact factor 0.2 (Scopus, 2020). (https://jnsbm.com/jnsbmsite/wp-content/uploads/2021/07/JNatScBiolMed-9-2-278.pdf).
15) Lekar A.V., Borisenko S.N., Vetrova E.V., Maksimenko E.V., Khizrieva S.S., Borisenko N.I., Minkin V.I. New fast “One-pot" Technique for the Production of Glycyrrhetinic Acid from the Roots of licorice (Glycyrrhiza glabra) // Natural Product Communications, 2018, Vol. 13, No. 7, pp.1934578X1801300709. DOI: 10.1177/1934578x1801300709. RSCI, Web of Science Core Collection, Scopus, Impact factor 0.986. (https://journals.sagepub.com/doi/10.1177/1934578X1801300709).
16) Vetrova E.V., Maksimenko E.V., Borisenko S.N., Lekar A.V., Borisenko N.I., Minkin V.I. Extraction of Rutin and Quercetin Antioxidants from the Buds of Sophora Japonica (Sophora japonica L.) by Subcritical Water // Russian Journal of Physical Chemistry B, 2017, Vol. 11, No.7 pp. 1202-1206. DOI: 10.1134/s1990793117070193. RSCI, Web of Science Core Collection, Scopus, Impact factor 0.823 (2020). (https://link.springer.com/article/10.1134/S1990793117070193).
17) Vetrova E.V., Lekar' A.V., Borisenko N.I. Mass spectrometric analysis of supramolecular complexes of glycyrrhizic acid and simvastatin // Chemistry of natural compounds, 2017, Vol. 53, No. 2, pp. 304-309. DOI: 10.1007/s10600-017-1975-6. RSCI, Web of Science Core Collection, Scopus, Impact factor 0.809 (2020). (https://link.springer.com/article/10.1007/s10600-017-1975-6).
18) Vetrova E.V., Kurbatov S.V., Borisenko S.N., Lekar A.V., Khizrieva S.S., Borisenko N.I., Minkin V.I. Synthesis of Phenanthrene alkaloids from herbal Aporphine alkaloids in subcritical water using synthesis of Seco-Glaucine as an example // Russian Journal of Physical Chemistry B, 2017, Vol. 11, No. 8, pp. 1255-1259. DOI: 10.1134/s1990793117080140. RSCI, Web of Science Core Collection, Scopus, Impact factor 0.823 (2020). (https://link.springer.com/article/10.1134/S1990793117080140).
19) Vetrova E.V., Borisenko N.I., Hizrieva S.S., Bugaeva A.F. The study of antioxidant activity of the aporphine alkaloid of glaucine and the phenanthrene alkaloid of seco-glaucine obtained in subcritical water // Khimiya Rastitel'nogo Syr'ya. 2017. No. 1. P. 85-91. (in Russ.). (http://journal.asu.ru/index.php/cw/article/view/1383).
20) Vetrova E.V., Maksimenko E.V., Khizrieva S.S., Bugaeva A.F., Borisenko N.I., Minkin V.I. A simple way for the preparation of natural antioxidant quercetin from rutin by subcritical water // Journal of natural science, biology, and medicine, 2017, Vol. 8, No. 2, pp. 213. DOI: 10.4103/0976-9668.210009. Scopus, Impact factor 0.2 (Scopus, 2020). (https://jnsbm.org/article/391).
21) Sushkova S.N., Minkina T.M., Mandzhieva S.S., Vasilyeva G.K., Borisenko N.I., Turina I.G., Bolotova O.V., Varduni T.V., Kızılkaya R. New alternative method of benzo[a]pyrene extraction from soils and its approbation in soil under technogenic pressure // Journal of Soils and Sediments. 2016. Vol. 16. N 4. P. 1323-1329. [Web of Science, Scopus, Q1, IF 2.90, doi.org/10.1007/s11368-015-1104-8].
22) Filonova O.V., Lekar A.V., Borisenko S.N., Vetrova E.V., Maksimenko E.V., Borisenko N.I., Minkin V.I. Hydrolysis of aralosides from Manchurian aralia to oleanolic acid and its derivatives in subcritical water // Russian Journal of Physical Chemistry B. 2016. Vol. 10. N 7. P. 1085-1091. [Web of Science, Scopus, Q4, IF 0.58, doi.org/10.1134/S1990793116070071].
23) Borisenko S.N., Lekar A.V., Vetrova E.V., Filonova O.V., Borisenko N.I. A mass spectrometry study of the self-association of glycyrrhetinic acid molecules // Russian Journal of Bioorganic Chemistry. 2016. Vol. 42. N 7. P. 716-720. [Web of Science, Scopus, Q4, IF 0.74, doi.org/10.1134/S1068162016070037].
24) E.V. Vetrova, N. I. Borisenko, O.V. Filonova. Mass spectrometry of self-assembled supramolecular structures of glycyrrhetic acid with benzimidazole // Chemistry of Natural Compounds. 2016. V. 52. Iss. 2. P. 262-265.
25) E.V. Vetrova, A.V. Lekar’, E.V. Maksimenko, S.S. Khizrieva, A.F. Bugaeva, N.I. Borisenko. MASS SPECTROMETRY SUPRAMOLECULAR COMPLEXES GLYCYRRHIZIC ACID, AND STREPTOMYCIN // Khimiya Rastitel'nogo Syr'ya, 2016. No. 3. P. 27-33. (in Russ.). URL: http://journal.asu.ru/cw/article/view/1175.
26) O.V. Filonova, A.V. Lekar, S.N. Borisenko, E.V. Maksimenko, E.V. Vetrova, N.I. Borisenko, and V.I. Minkin. Synthesis of Glycyrrhetinic Acid Monoglycoside by Hydrolysis of Glycyrrhizic Acid in Subcritical Water // Russian Journal of Physical Chemistry B. 2015. V. 9. Iss. 8. P. 1-4.
27) A.V. Lekar, S.N. Borisenko, E.V. Vetrova, O.V. Filonova, E.V. Maksimenko, N.I. Borisenko, V.I. Minkin. Study of an Acid-Free Technique for the Preparation of Glycyrrhetinic Acid from Ammonium Glycyrrhizinate in Subcritical Water // Natural Product Communications. 2015. V. 10. Iss. 11. P. 1801-1803.
28) E.V. Vetrova, A.V. Lekar, O.V. Filonova, S.N. Borisenko, E.V. Maksimenko, and N.I. Borisenko. Mass spectrometry of self-organizing supramolecular structures of glycyrrhetic acid and levomycetin // Chemistry of Natural Compounds. 2015. V. 51. N 3. P. 500-504.
29) E.V. Vetrova, A.V. Lekar, O.V. Filonova, S.N. Borisenko, E.V. Maksimenko, and N.I. Borisenko. Study of self-association of simvastatin using mass spectrometry with electrospray ionization // Journal of Applied Spectroscopy. 2015. V. 82. Iss. 3. P. 337-342.
30) A.V. Lekar, O.V. Filonova, S.N. Borisenko, E.V. Maksimenko, N.I. Borisenko, and V.I. Minkin. Extraction of Chlorogenic Acid from Marsh Cinquefoil Comarum palustre L. in Subcritical Water // Russian Journal of Bioorganic Chemistry. 2015. V. 41. Iss. 7. P. 762-766.
31) A.V. Lekar, O.V. Filonova, S.N. Borisenko, E.V. Maksimenko, E.V. Vetrova, N.I. Borisenko, V. I. Minkin. Subcritical Water Extraction of Chlorogenic Acid from Green Coffee Beans // Russian Journal of Physical Chemistry B. 2015. V. 9. Iss. 7. P. 1;5.
32) E.V. Vetrova, A.V. Lekar, O.V. Filonova, S.N. Borisenko, E.V. Maksimenko, N.I. Borisenko. Study of molecular complexation of glycyrrhizic acid with chloramphenicol by electrospray ionization mass spectrometry // Journal of Natural Science, Biology and Medicine. 2015. V. 6. Iss.1. P. 40-43.
33) S.N. Borisenko, A.V. Lekar’, E.V. Vetrova, O.V. Filonova, N.I. Borisenko. MASS SPECTROMETRIC STUDY OF MOLECULES SELF-ASSEMBLY OF GLYCYRRHETINIC ACID // Khimiya Rastitel'nogo Syr'ya, 2015. No. 1. P. 89-94. (in Russ.). URL: http://journal.asu.ru/cw/article/view/229.
